Objective To explore the knowledge,attitudes and practice(KAP) status of preventing medical device related pressure injury(MDRPI) among clinical nurses working in ICU,and to examine factors affecting nurses’ KAP. Methods Questionnaire was used to measure nurses’ KAP of preventing MDRPI. Data was collected from 1,664 nurses in 18 tertiary hospitals and 18 secondary hospitals in Henan Province to analyze nurses’ KAP of preventing MDRPI and to explore its influencing factors. Results A total of 1,610 valid questionnaires were collected. The scores of overall KPA,knowledge,attitudes,and practice were 136.93±20.42,50.21±11.28,38.14±5.46 and 48.58±9.03,respectively. The results from multiple linear regression analysis showed that hospital level was the main influencing factor of nurses’ knowledge of preventing MDRPI;hospital level,professional title,position and department category were the main influencing factors of nurses’ attitudes of preventing MDRPI;knowledge,attitudes,age,gender and position were the main influencing factors of nurses’ practice of preventing MDRPI. Conclusion Nurses working in ICU have a positive attitude towards the prevention of MDRPI,but their knowledge and practice need to be improved. According to different characteristics of nurses,nursing managers should carry out training on the knowledge of prevention of MDRPI to establish a positive attitude,so as to drive the change of nursing practice and improve the quality of nursing in ICU.